abstract：BACKGROUND:Full-scale implementation of lung cancer screening in the United States will increase detection of early stages. This study was aimed at assessing the capacity required for treating those cancers. METHODS:A well-established microsimulation model was extended with treatment data from the National Cancer Data...

journal_title：Cancer

authors： Blom EF,Ten Haaf K,Arenberg DA,de Koning HJ

更新日期：2019-06-15 00:00:00

abstract：:Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive pot...

journal_title：Cancer

authors： Varughese RS,Lam WS,Marican AABH,Viganeshwari SH,Bhave AS,Syn NL,Wang J,Wong AL,Kumar AP,Lobie PE,Lee SC,Sethi G,Goh BC,Wang L

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated dose, and evidence of antileukemic activity for DFP-10917 administered...

journal_title：Cancer

authors： Kantarjian HM,Jabbour EJ,Garcia-Manero G,Kadia TM,DiNardo CD,Daver NG,Borthakur G,Jain N,Waukau JB,Kwari MI,Ravandi F,Anderson BD,Iizuka K,Jin C,Zhang C,Plunkett WK

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:The current study evaluated whether the risk of developing thyroid cancer in Asian women was associated with infertility and the use of fertility drugs. METHODS:The authors conducted a large, retrospective cohort study using Taiwan's National Health Insurance Research Database. From the insurance claims dat...

journal_title：Cancer

authors： Ding DC,Chen W,Wang JH,Lin SZ,Sung FC

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Studies postulate that certain religious beliefs related to medical care influence the end-of-life (EOL) medical decision making and care of patients with advanced cancer. Because to the best of the authors' knowledge no current measure explicitly assesses such beliefs, in the current study the authors intro...

journal_title：Cancer

authors： Balboni TA,Prigerson HG,Balboni MJ,Enzinger AC,VanderWeele TJ,Maciejewski PK

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Despite growing evidence and support for shared decision making, little is known about the experiences of parents who hold more active roles than they wish. METHODS:This was a prospective cohort study of 372 parents of children with cancer and their oncologists at 2 academic pediatric hospitals. Parents wer...

journal_title：Cancer

authors： Sisk BA,Kang TI,Goldstein R,DuBois JM,Mack JW

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Aberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome-wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs. METHODS:Thirty-three tissue samples were analyzed: they included sa...

journal_title：Cancer

authors： Tirosh A,Mukherjee S,Lack J,Gara SK,Wang S,Quezado MM,Keutgen XM,Wu X,Cam M,Kumar S,Patel D,Nilubol N,Tyagi MV,Kebebew E

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:This multicenter, retrospective study explored the value of oncogene driver subtype, programmed death-1 ligand (PD-L1) status, and smoking status for predicting which patients with oncogene-driven non-small cell lung cancer (NSCLC) would benefit from treatment with programmed death-1 (PD-1)/PD-L1 inhibitors....

journal_title：Cancer

authors： Ng TL,Liu Y,Dimou A,Patil T,Aisner DL,Dong Z,Jiang T,Su C,Wu C,Ren S,Zhou C,Camidge DR

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Low-grade gliomas (LGGs) and low-grade glioneuronal tumors (LGGNTs) diagnosed during the first year of life carry unique clinical characteristics and challenges in management. However, data on the treatment burden, outcomes, and morbidities are lacking. METHODS:A retrospective study of LGGs and LGGNTs diagn...

journal_title：Cancer

authors： Liu APY,Hastings C,Wu S,Bass JK,Heitzer AM,Ashford J,Vestal R,Hoehn ME,Ghazwani Y,Acharya S,Conklin HM,Boop F,Merchant TE,Gajjar A,Qaddoumi I

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Glembatumumab vedotin is an antibody-drug conjugate that produced preliminary clinical activity against advanced melanoma in a phase 1 dose-escalation trial. The objective of the current study was to investigate further the antitumor activity of glembatumumab vedotin at the recommended phase 2 dose in heavil...

journal_title：Cancer

authors： Ott PA,Pavlick AC,Johnson DB,Hart LL,Infante JR,Luke JJ,Lutzky J,Rothschild NE,Spitler LE,Cowey CL,Alizadeh AR,Salama AK,He Y,Hawthorne TR,Bagley RG,Zhang J,Turner CD,Hamid O

更新日期：2019-04-01 00:00:00

abstract：:In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SO...

journal_title：Cancer

authors： Koff JL,Waller EK

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...

journal_title：Cancer

authors： Koelmeyer LA,Borotkanics RJ,Alcorso J,Prah P,Winch CJ,Nakhel K,Dean CM,Boyages J

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a+ )/CD207+ histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive ...

journal_title：Cancer

authors： Chellapandian D,Hines MR,Zhang R,Jeng M,van den Bos C,Santa-María López V,Lehmberg K,Sieni E,Wang Y,Nakano T,Williams JA,Fustino NJ,Astigarraga I,Dunkel IJ,Abla O,van Halteren AGS,Pei D,Cheng C,Weitzman S,Sung L,N

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Colonoscopy is the most widely used colorectal cancer (CRC) screening test in the United States. Through the detection and removal of potentially precancerous polyps, it can prevent CRC. However, CRC screening remains low among adults who are recommended for screening. The New Hampshire Colorectal Cancer Scr...

journal_title：Cancer

authors： Rice K,Sharma K,Li C,Butterly L,Gersten J,DeGroff A

更新日期：2019-02-15 00:00:00

abstract：:For women who are candidates for menopausal hormone therapy (MHT), estrogen can provide relief from symptomatic menopause, decrease rates of chronic illnesses, and improve health-related quality of life. However, confusion surrounds the evidence regarding the impact of exogenous estrogen and progesterone on the breast...

journal_title：Cancer

authors： Temkin SM,Mallen A,Bellavance E,Rubinsak L,Wenham RM

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Increasing knowledge of cancer genomes has triggered the development of specific targeted inhibitors, thus providing a valuable therapeutic pool. METHODS:In this report, the authors analyze the presence of targetable alterations in 136 tumor samples from 92 patients with melanoma using a comprehensive appro...

journal_title：Cancer

authors： Appenzeller S,Gesierich A,Thiem A,Hufnagel A,Jessen C,Kneitz H,Regensburger M,Schmidt C,Zirkenbach V,Bischler T,Schilling B,Siedel C,Goebeler ME,Houben R,Schrama D,Gehrig A,Rost S,Maurus K,Bargou R,Rosenwald A,Sch

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:A growing body of research has demonstrated that individuals who live in neighborhoods with more severe socioeconomic deprivation may have higher risks for colorectal cancer (CRC). However, previous studies have examined neighborhood socioeconomic status (SES) at only 1 point in time, and it is unclear wheth...

journal_title：Cancer

authors： Zhang D,Matthews CE,Powell-Wiley TM,Xiao Q

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Clips are often placed to mark axillary nodes with biopsy-confirmed metastases in patients with breast cancer. The evaluation of clipped nodes after chemotherapy can identify patients who have eradication of nodal disease. The goal of this study was to determine whether preoperative fine-needle aspiration (F...

journal_title：Cancer

authors： Caudle AS,Kuerer HM,Krishnamurthy S,Shin K,Hobbs BP,Ma J,Mittendorf EA,Washington AC,DeSnyder SM,Black DM,Hunt KK,Yang WT

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The causal relation between high-risk human papillomavirus (HPV) and cervical cancer and its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined the impact of the baseline HPV status on the future risk of cervical intraepithelial neoplasia grade 2 or worse...

journal_title：Cancer

authors： Fröberg M,Östensson E,Belkić K,Oštrbenk A,Poljak M,Mints M,Arbyn M,Andersson S

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Biological aging pathways accelerated by cancer treatments may be a mechanism for cognitive impairment in cancer survivors. The goal of the current study was to examine whether indicators of biological aging, namely elevated levels of DNA damage, reduced telomerase enzymatic activity, and shorter peripheral ...

journal_title：Cancer

authors： Carroll JE,Van Dyk K,Bower JE,Scuric Z,Petersen L,Schiestl R,Irwin MR,Ganz PA

更新日期：2019-01-15 00:00:00

abstract：:Despite few effective therapies, only a small percentage of patients diagnosed with myelodysplastic syndromes (MDS) in the United States are enrolled in prospective, interventional clinical trials. MDS-specific barriers to trial accrual include a high frequency of elderly patients with comorbid conditions, atypical di...

journal_title：Cancer

authors： Steensma DP,Brunner AM,DeZern AE,Garcia-Manero G,Komrokji RS,Odenike OS,Roboz GJ,Savona MR,Stone RM,Sekeres MA

更新日期：2018-12-15 00:00:00

abstract：:Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. He...

journal_title：Cancer

authors： Napel S,Mu W,Jardim-Perassi BV,Aerts HJWL,Gillies RJ

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Parents of children with cancer have unmet information needs regarding future limitations resulting from cancer or its treatment. Prior research has demonstrated that, in early care discussions, clinicians focus on the acute effects of therapy rather than long-term limitations, partly due to worries of causi...

journal_title：Cancer

authors： Greenzang KA,Cronin AM,Kang TI,Mack JW

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Despite its established benefits, palliative care (PC) is rarely utilized for hematopoietic stem cell transplant (HSCT) patients. We sought to examine transplant physicians' perceptions of PC. METHODS:We conducted a cross-sectional survey of transplant physicians recruited from the American-Society-for-Bloo...

journal_title：Cancer

authors： El-Jawahri A,LeBlanc TW,Burns LJ,Denzen E,Meyer C,Mau LW,Roeland EJ,Wood WA,Petersdorf E

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:To eliminate cranial irradiation (CrRT)-related sequelae and to minimize the adverse impact of traumatic lumbar puncture (TLP) with blasts, the Taiwan Pediatric Oncology Group (TPOG) introduced a modified central nervous system (CNS)-directed regimen characterized by delayed triple intrathecal therapy (TIT) ...

journal_title：Cancer

authors： Yeh TC,Liang DC,Hou JY,Jaing TH,Lin DT,Yang CP,Peng CT,Hung IJ,Lin KH,Hsiao CC,Jou ST,Chiou SS,Chen JS,Wang SC,Chang TK,Wu KH,Sheen JM,Yen HJ,Chen SH,Lu MY,Li MJ,Chang TT,Huang TH,Chang YH,Chen SH,Yang Y

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Chemoradiation with 5-fluorouracil and mitomycin remains the standard of care for squamous cell carcinoma (SCC) of the anal canal. A prolonged treatment time is associated with inferior disease-specific outcomes. Radiation Therapy Oncology Group trial 0529 demonstrated decreased toxicity and fewer treatment ...

journal_title：Cancer

authors： Elson JK,Kachnic LA,Kharofa JR

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:Cancer costs should be discussed by patients and providers, but information is not readily available. Results from recently published studies (in the last 5 years) on direct and indirect cancer costs may help guide these discussions. METHODS:The authors reviewed studies published between 2013 and 2017 that ...

journal_title：Cancer

authors： Pisu M,Henrikson NB,Banegas MP,Yabroff KR

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Cancer survivors face psychosocial issues that increase their risk of suicide. This study examined the risk of suicide across cancer sites, with a focus on survivors of head and neck cancer (HNC). METHODS:The Surveillance, Epidemiology, and End Results 18-registry database (from 2000 to 2014) was queried fo...

journal_title：Cancer

authors： Osazuwa-Peters N,Simpson MC,Zhao L,Boakye EA,Olomukoro SI,Deshields T,Loux TM,Varvares MA,Schootman M

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:For many childhood cancers, survival is lower among non-Hispanic blacks and Hispanics in comparison with non-Hispanic whites, and this may be attributed to underlying socioeconomic factors. However, prior childhood cancer survival studies have not formally tested for mediation by socioeconomic status (SES). ...

journal_title：Cancer

authors： Kehm RD,Spector LG,Poynter JN,Vock DM,Altekruse SF,Osypuk TL

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:It is questionable whether enrollment on clinical trials offers any survival advantage at the population level over standard-of-care treatment. The objectives of this study were to describe the impact of trial enrollment on event-free survival and overall survival in pediatric acute myeloid leukemia (AML) us...

journal_title：Cancer

authors： Truong TH,Pole JD,Barber R,Dix D,Kulkarni KP,Martineau E,Randall A,Stammers D,Strahlendorf C,Strother D,Sung L

更新日期：2018-10-15 00:00:00

abstract：:Increasing scientific attention is focused on the gut-brain axis, including the ability of the gastrointestinal (GI) tract to modulate central nervous system function. Changes in the intestinal microbiome can influence affective-like behavior, cognitive performance, fatigue, and sleep in rodents and humans. Patients w...

journal_title：Cancer

authors： Jordan KR,Loman BR,Bailey MT,Pyter LM

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Partial nephrectomy (PN) is recommended for localized T1a (≤4 cm) renal masses and is preferred over radical nephrectomy (RN) for amenable T1b/T2 (>4 cm) tumors. The objective of the current study was to assess overall survival (OS) differences between PN and RN in patients with T1 and T2 renal cell carcinom...

journal_title：Cancer

authors： Ristau BT,Handorf EA,Cahn DB,Kutikov A,Uzzo RG,Smaldone MC

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:To the authors' knowledge, outcomes and prognostic tools have yet to be clearly defined in patients with metastatic renal cell carcinoma (mRCC) who are treated with immuno-oncology (IO) checkpoint inhibitors (programmed death-ligand 1 [PD-L1] inhibitors). In the current study, the authors aimed to establish ...

journal_title：Cancer

authors： Yip SM,Wells C,Moreira R,Wong A,Srinivas S,Beuselinck B,Porta C,Sim HW,Ernst DS,Rini BI,Yuasa T,Basappa NS,Kanesvaran R,Wood LA,Canil C,Kapoor A,Fu SYF,Choueiri TK,Heng DYC

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:In the United States, only approximately 0.4% of all melanomas are diagnosed in patients aged <20 years. To the authors' knowledge, melanoma in pediatric members of melanoma-prone families has not been fully investigated to date. The objective of the current study was to evaluate pediatric patients with mela...

journal_title：Cancer

authors： Goldstein AM,Stidd KC,Yang XR,Fraser MC,Tucker MA

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:The aim of this study was to determine and compare the added prognostic value of screening tools, geriatric assessment (GA) components, and GA summaries to clinical information for overall survival (OS) in older patients with cancer. METHODS:A screening and a 10-item GA were systematically performed in pati...

journal_title：Cancer

authors： Kenis C,Baitar A,Decoster L,De Grève J,Lobelle JP,Flamaing J,Milisen K,Wildiers H

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:The incidence of hepatocellular carcinoma (HCC) has been rising rapidly in the United States. California is an ethnically diverse state with the largest number of incident HCC cases in the country. Characterizing HCC disparities in California may inform priorities for HCC prevention. METHODS:By using data f...

journal_title：Cancer

authors： Yang B,Liu JB,So SK,Han SS,Wang SS,Hertz A,Shariff-Marco S,Lin Gomez S,Rosenberg PS,Nguyen MH,Hsing AW

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Glucocorticoids can lead to weight gain during cancer treatment, but to the authors' knowledge, little is known regarding their long-term effects in childhood cancer survivors (CCS). METHODS:As part of the Swiss Childhood Cancer Survivor Study, the authors sent a questionnaire to CCS aged <21 years at diagn...

journal_title：Cancer

authors： Belle FN,Kasteler R,Schindera C,Bochud M,Ammann RA,von der Weid NX,Kuehni CE,Swiss Pediatric Oncology Group (SPOG).

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Multidisciplinary management of head and neck cancer (HNC) must reconcile increasingly sophisticated subspecialty care with timeliness of care. Prior studies examined the individual effects of delays in diagnosis-to-treatment interval, postoperative interval, and radiation interval but did not consider them ...

journal_title：Cancer

authors： Ho AS,Kim S,Tighiouart M,Mita A,Scher KS,Epstein JB,Laury A,Prasad R,Ali N,Patio C,Clair JM,Zumsteg ZS

更新日期：2018-08-01 00:00:00

abstract：:Molecular characterization of hepatocellular carcinoma (HCC) has greatly improved our understanding of disease pathogenesis. Mutational analysis, RNA and microRNA expression profiling, and epigenetic characterization have revealed common aberrations in oncogenes and tumor suppressors that correlate with disease biolog...

journal_title：Cancer

authors： Erstad DJ,Fuchs BC,Tanabe KK

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Patients who travel a long distance (≥50 miles) for cancer care have improved outcomes. However, to the authors' knowledge, the prevalence of long travel distances for treatment by patients with head and neck squamous cell carcinoma (HNSCC), and the effect of travel distance on overall survival (OS), remains...

journal_title：Cancer

authors： Graboyes EM,Ellis MA,Li H,Kaczmar JM,Sharma AK,Lentsch EJ,Day TA,Hughes Halbert C

更新日期：2018-08-01 00:00:00